Stage 1: Establish the safety profile for all initial doses. | Using DLT as toxicity measure | Using quasi-continuous toxicity measure (nTTP) | Stage 2: Adaptive randomization based on efficacy outcomes.

Overview | Scenario 1: Monotone dose-efficacy | One Trial Simulation | Stage 1: Establish the safety profile for all initial doses. | Stage 2: Adaptive randomization based on efficacy outcomes. | 100 Trials Simulations | Scenario 2: Non-monotone dose-efficacy | Stage 1: Establish the safety profile for all initial doses

Overview | Statistical model for nTTP within the iAdapt framework | Simulation example | Specify design parameters | Calculate mean nTTP (mnTTP) and corresponding DLT rate per dose, and specify hypotheses | Simulate a single trial | Stage 1: Establish the safety profile for all initial doses. | Stage 2: Adaptive randomization based on efficacy outcomes. | Simulate 100 trials